<i>CENP‐E</i> haploinsufficiency causes chromosome misalignment and spindle assembly checkpoint activation in the spermatogonia
CENP-E depletion disrupts the recruitment of key checkpoint proteins, including BubR1, Bub1, KIF2C, and Aurora B, indicating a causal relationship between chromosome misalignment and spindle assembly checkpoint activation in spermatogonia. Our findings demonstrate that CENP-E regulates kinetochore-microtubule attachment, chromosome alignment, and spindle assembly checkpoint in spermatogonia.
Authors
- Ya‐Lan Wei (ORCID: https://orcid.org/0000-0003-4124-4135)
- Zhen‐Yu She (ORCID: https://orcid.org/0000-0001-5042-474X)
- Shan Wu (ORCID: https://orcid.org/0000-0001-8539-3808)
- Jie Chen (ORCID: https://orcid.org/0000-0003-2151-5276)
- Yu‐Peng Liu (ORCID: https://orcid.org/0000-0002-2716-0050)
- Yue Xu (ORCID: https://orcid.org/0000-0002-4615-5441)
- Han‐Kai Fang
- Jian‐Fan Chen
- Zhao‐Yang Deng
- Jie‐Jie He
Institutions
- Fujian Medical University (CN)
- Fuzhou Maternity and Child Health Care Hospital (CN)
Publication Details
- Journal
- Andrology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1111/andr.13834
- Citations
- 4
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.30
Funders
- National Natural Science Foundation of China