Forty‐hertz sensory entrainment impedes kindling epileptogenesis and reduces amyloid pathology in an Alzheimer disease mouse model
Forty-hertz sensory entrainment slows epileptogenesis in the mouse amygdala kindling model. Although this intervention improves Aβ pathology in 5xFAD mice, the observed antiepileptogenic effect may also relate to effects on glia, because mice without Aβ plaques (i.e., WT) also experienced antiepileptogenic effects of the intervention.
Authors
- Nigel C. Jones (ORCID: https://orcid.org/0000-0002-1080-8439)
- Anna Harutyunyan (ORCID: https://orcid.org/0000-0002-6165-5639)
- Zhibin Chen (ORCID: https://orcid.org/0000-0002-1888-6917)
- Matthew R. Hudson (ORCID: https://orcid.org/0000-0001-5016-735X)
- Jennifer Tinston
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- The Alfred Hospital (AU)
- Monash University (AU)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1111/epi.18222
- Citations
- 3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Australian Research Council
- National Health and Medical Research Council