Case study of a neuroendocrine tumor of uncertain origin: single-cell transcriptomics unravels potential primary location
This case demonstrates the value of integrating scRNA-seq and WES for the molecular characterization of complex NETs. Identifying the tumor's pancreatic origin informed a targeted management approach, avoiding unnecessary systemic treatment and underscoring the potential of single-cell approaches in personalized oncology.
Authors
- Ekaterina Avsievich (ORCID: https://orcid.org/0000-0002-4563-650X)
- Zoya Antysheva (ORCID: https://orcid.org/0000-0003-2982-2123)
- Mark Voloshin (ORCID: https://orcid.org/0000-0002-2302-3542)
- Olga Glazova (ORCID: https://orcid.org/0000-0001-7199-1866)
- Pavel Volchkov (ORCID: https://orcid.org/0000-0001-9794-6297)
- Denis Maksimov (ORCID: https://orcid.org/0000-0002-2937-6082)
- Nikolay Karnaukhov (ORCID: https://orcid.org/0000-0003-0889-2720)
- Ilia Feidorov (ORCID: https://orcid.org/0000-0001-8369-5116)
- Julia Krupinova (ORCID: https://orcid.org/0000-0001-7963-5022)
- Diana Salimgereeva (ORCID: https://orcid.org/0000-0001-9742-3955)
- Natalia Bodunova (ORCID: https://orcid.org/0000-0001-6045-7334)
- Alesia Maluchenko
- Frolova Tatyana
Institutions
- Moscow Clinical Scientific Center (RU)
- Medical Technologies (Czechia) (CZ)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1007/s00432-024-06071-z
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Higher Education of the Russian Federation