Molecular dependencies and genomic consequences of a global DNA damage tolerance defect
Our data highlight the essential contribution of the DDT system to genome maintenance and type 3 deletions as mutational signature of replication stress. The unique characteristics of type 3 deletions implicate the existence of a novel deletion pathway in mice and humans that is counteracted by DDT.
Authors
- Maaike Kreft (ORCID: https://orcid.org/0000-0003-1301-2898)
- Bas Pilzecker (ORCID: https://orcid.org/0000-0002-3407-9197)
- Ben Morris (ORCID: https://orcid.org/0000-0002-9850-6071)
- Shirley Ormel
- Aldo Spanjaard (ORCID: https://orcid.org/0000-0002-3189-6941)
- Olimpia Alessandra Buoninfante
- Paul C.M. van den Berk (ORCID: https://orcid.org/0000-0003-1213-253X)
- Roderick L. Beijersbergen (ORCID: https://orcid.org/0000-0003-0116-4130)
- Daniël de Groot
- Matilda Ayidah
- Heinz Jacobs (ORCID: https://orcid.org/0000-0001-6227-9850)
- Joyce J. I. Catsman
- Cor Lieftink (ORCID: https://orcid.org/0000-0002-2754-4150)
- Ronak Shah
Institutions
- The Netherlands Cancer Institute (NL)
- Oncode Institute (NL)
Publication Details
- Journal
- Genome biology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s13059-024-03451-z
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- KWF Kankerbestrijding