Role of Immunity in Hashimoto’s Thyroiditis diseases in Diyala province

This study used to evaluate the Effect of Some Cytokines (IL-5, IL-18, IL-23 and TGEB1) levels in Hashimoto’s Thyroiditis diseases and the study was carried out between February and August 2023.The study groups in involved Group for Hashimoto’s disease: 60 people with thyroid problems that have been clinically and 30 people who seemed healthy made up the control group. All participants had taken a venous blood samples and thyroid hormone levels (T3, T4 and TSH) as well as cytokine levels (IL-5, IL-18, IL-23 and TGEB1) were measured by Minivoids device and ELISA, respectively. The study shown ahigh levels of T3 and TSH with low levels for T4 in patients compare to healthy groups. There was a significant increase in Cytokines levels (IL-5, IL-18, IL-23 and TGEB1) in patients’ group (14.423±2.549, 185.13±5.058, 85.07±6.701, 88.025±4.54) compare to healthy groups (8.581±0.529,161.38±4.341, 45.25±5.758, 69.666±5.168) respectively. Serum IL-5 levels have a positive associated with thyroxine (rs=0.428**, p<0.001), IL-18 levels have a positive associated TGFB1 (rs=0.258*, p<.046), IL-23 levels have a positive associated TGFB1 (rs=0.392**, p<0.002). The results suggest that cytokines (IL-5, IL-18, IL-23 and TGEB1) levels may show a role in the pathogenesis of HT.