Evaluation of gray-matter and white-matter microstructural abnormalities in children with growth hormone deficiency: a comprehensive assessment with synthetic magnetic resonance imaging
Altered T1 and T2 relaxometry values and MVF in gray and white matter indicate the relevance of the default mode, central executive, somatosensory, visual, and cerebellar networks underlying pediatric GHD, which may imply the involvement of the GH-IGF-1 axis and myelin in the pathophysiological mechanism of GHD. Moreover, the brain microstructure alteration in cortico-striatal-limbic loop might be influenced by the GH-IGF-1 axis and play an important role in the behavioral impairments in children with GHD.
Authors
- Zhiyun Yang (ORCID: https://orcid.org/0000-0002-6139-9049)
- Gerald L. Cheung
- Long Qian (ORCID: https://orcid.org/0000-0002-9707-1096)
- Zilin Yan
- Cui Wei
- Qiuli Chen (ORCID: https://orcid.org/0000-0002-9550-7327)
- Huaqiong Qiu
- Yuli Cheng (ORCID: https://orcid.org/0000-0003-4464-3684)
- Shu Su (ORCID: https://orcid.org/0000-0001-8704-9752)
- Liping Lin (ORCID: https://orcid.org/0000-0003-3641-8102)
- Shuzhen Huang
- Weifeng Hou
Institutions
- Sun Yat-sen University (CN)
- Peking University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Quantitative Imaging in Medicine and Surgery
- Published
- 2024-12-31
- DOI
- https://doi.org/10.21037/qims-24-1404
- Citations
- 1
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.36
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province