The correlation between contrast-enhanced ultrasound Liver Imaging Reporting and Data System classification and differentiation grades of combined hepatocellular carcinoma-cholangiocarcinoma

cHCC-CCAs classified as LR-M based on CEUS LI-RADS tend to be poorly differentiated, but the dominant pathologic component could be either HCC or ICC. cHCC-CCA lesions with ICC predominance were associated with early washout, whereas HCC-predominant lesions were associated with late washout. Additionally, the margins of HCC-predominant lesions were more ill-defined and irregular in shape compared to those of ICC-predominant lesions.