Reduced Neuroplasticity Decreases Resilience to Depression and Anxiety in a Mouse Model

It is well studied that adult hippocampal neurogenesis (AHN) increases resilience to depression-like behaviors improving cognitive functions and mood regulation. Also, improving AHN helps with the recovery of stress induced symptoms but the reason remains elusive. We use the mouse model by blocking the NMDA receptors in AHN neurons to evaluate the effect of reducing neuroplasticity on stress induced symtoms.