METTL1 mediates PKM m7G modification to regulate CD155 expression and promote immune evasion in colorectal cancer
Our findings reveal a general mechanism by which METTL1/PKM2/H3K9la signaling regulates RNA metabolism and highlight METTL1 targeting as a potential strategy for CRC immunotherapy.
Authors
- Fang Wang (ORCID: https://orcid.org/0000-0003-0626-7796)
- Yan Yang (ORCID: https://orcid.org/0000-0002-7883-0798)
- Hairong Sun
- Chen Yang (ORCID: https://orcid.org/0000-0002-3314-5252)
- Heping Xu (ORCID: https://orcid.org/0000-0003-4000-931X)
- Xiaowei Qi (ORCID: https://orcid.org/0000-0002-5876-4957)
- Fang Zheng (ORCID: https://orcid.org/0000-0001-6067-9914)
- Dongyan Cai
- Guifang Li (ORCID: https://orcid.org/0000-0002-4623-2611)
- Yanyan Feng (ORCID: https://orcid.org/0009-0003-3222-667X)
- Zilong He (ORCID: https://orcid.org/0000-0002-7111-7770)
- Yong Mao (ORCID: https://orcid.org/0009-0007-3956-681X)
Institutions
- Jiangnan University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Wuxi Fourth People's Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s12967-024-05991-1
- Citations
- 26
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.08
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Jiangnan University
- Zhejiang University
- Wu Jieping Medical Foundation