Evaluating the gene expression linked to oxidative stress in the eyes of adult male Zebrafish (Danio rerio) after the treated to 4 - nonylphenol

Endocrine-disrupting compounds (EDCs) are molecules that can be made by humans or by nature.They can imitate, block, or intervene body's natural hormones, which are part of the endocrine system.A lot of health problems have been linked to these chemicals [16].Although they may potentially have an impact on hormone synthesis and metabolism, the majority of EDCs directly mimic or inhibit hormone receptor action.Endocrine disruptors are found in many everyday products, including certain cosmetics, food and drink packaging, toys, carpets, and pesticides.Some chemicals that have flame-retardant qualities also are endocrine disruptors.These substances may enter the body via the air, food, skin, and water.Although it is impossible to totally prevent or eliminate ABSTRACT: The phenolic endocrine disruptor molecule 4-nonylphenol (4-NP) is prevalent in several industrial goods and the environment, adversely affecting the health of people, animals, and aquatic organisms.It is necessary to assess the harmful impact of this contaminant on the ocular systems of aquatic animals.The investigation was done on adult male zebrafish exposed to 4-nonylphenol for 21 days.At the conclusion of the research, the expression of oxidative tress-related genes (sod, cat, nrf2) was assessed in the zebrafish eye.One hundred twenty mature zebrafish were categorized into four categories.The zebrafish in the first group were maintained in standard reverse osmosis (RO) water, whilst the second group was subjected to ethanol at a concentration of 10 l/L of water and designated as the vehicle group.Fish from two toxicity groups were subjected to 4-nonylphenol at concentrations of 100 and 200 g per liter of water.The mRNA expression levels of superoxide dismutase (SOD), catalase (CAT), and nuclear factor erythroid 2 related factor 2 (Nrf2) in the eyes of zebrafish exposed to 200 g of 4-nonylphenol per liter of water exhibited considerable downregulation.