PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation
PATL2 plays a critical role in regulating mRNA accumulation and decay in human oocytes, potentially through interactions with CPEB1 and TUT7, respectively. Mutations in PATL2 lead to oocyte meiosis defects by affecting the mRNA accumulation, mRNA translation, and direct binding to and stabilizing proteins related to cell cycle regulation, such as CCNB1 and CDC23. This study expands the mutational spectrum of PATL2 and provides new insights into the molecular mechanisms underlying PATL2 mutation-associated oocyte maturation disorders.
Authors
- Xiaomei Tong (ORCID: https://orcid.org/0000-0002-6982-445X)
- Wei Zheng (ORCID: https://orcid.org/0000-0002-1397-4176)
- Siya Liu
- Zhanhong Hu (ORCID: https://orcid.org/0000-0002-0990-4810)
- Rong Yan (ORCID: https://orcid.org/0000-0001-7925-1280)
- Mengru Lai (ORCID: https://orcid.org/0000-0003-0742-022X)
- Songying Zhang (ORCID: https://orcid.org/0000-0001-8044-6237)
- Jiamin Jin (ORCID: https://orcid.org/0000-0003-2725-840X)
- Yinli Zhang (ORCID: https://orcid.org/0000-0001-8353-9615)
- Huifang Jiang (ORCID: https://orcid.org/0000-0003-4087-205X)
- Shen Zhang (ORCID: https://orcid.org/0000-0003-3988-1442)
- Yingyi Zhang
- Peipei Ren (ORCID: https://orcid.org/0000-0002-2682-1304)
- Yan Zhou (ORCID: https://orcid.org/0000-0001-9352-7108)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Reproductive & Genetic Hospital CITIC-Xiangya (CN)
- Zhejiang Center for Disease Control and Prevention (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s13578-024-01341-2
- Citations
- 4
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Sir Run Run Shaw Hospital
- National Natural Science Foundation of China
- Key Technologies Research and Development Program
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Zhejiang Province