Changes in some biochemical indicators in psoriasis patients as a marker of disease activity

The elicitation of primary nature of biochemical shifts occurred at psoriatic disease and the prediction of interconnected subsequent changes in metabolic and inflammatory processes are important in predicting the dynamic development of pathological process and the choice of individual treatment. Objective — to assess disorders and correlations between main indicators of protein, fat, hydrocarbon and pigment metabolism and specifics of inflammatory processes in psoriatic patients against the clinical course of dermatosis. Materials and methods. We have analysed the results of clinical and laboratory examinations performed in respect of 62 psoriatic patients. All these patients have been analysed per their age, sex, prevalence and the type of skin rash as well as per the clinical disease form. Biochemical examinations have been conducted using appropriate sets of reagents. To establish the possible correlation between the indicators of biochemical blood analysis, we have calculated the correlation coefficient, which determines the nature of correlation between the studied variables. Results and discussion. The analysis of results received upon examining psoriatic patients indicated that microbial-viral associations, stress factors and genetic predisposition were the most frequent trigger factors of psoriatic disease, which corresponds to the data from literary sources. We have registered that the psoriaric disease of duration up to 5 years was the most common, and relapses manifested in its limited form against the background of the disease advanced stage; the prevalent psoriasis was more common for the hospital stage. Our study justifies that metabolic changes occurred in the overwhelming majority of examined patients of different age groups. At that, abnormalities of a number of indicators of protein, lipid, hydrocarbon and enzyme metabolism have been established. In addition, the expressiveness of corresponding changes correlated with the prevalence of skin psoriatic process and the duration of dermatosis course as well as the presence of pathology of a number of internal organs, in particular of gastrointestinal tract, hepatobiliary and cardiovascular systems, that suggest the presence of systemic disorders at psoriasis. Conclusions. The establishment of independent mechanisms existing between some changes in metabolic process parameters at psoriasis has a theoretical and practical significance in dermatology, which involves the use of medications to regulate the established disorders, the possibility to restore correlations as it will inevitably contribute to the achievement of clinical and preventive effect.