Non‐ <i>APOE</i> variants predominately expressed in smooth muscle cells contribute to the influence of Alzheimer's disease genetic risk on white matter hyperintensities
Alzheimer's disease (AD) risk factors such as apolipoprotein E (APOE) ε4, link to increased white matter hyperintensity volume (WMHV). WMHVs indicate vascular risk and neurovascular injury in AD. The broader genetic link between AD risk and WMHV is not fully understood. We quantify AD polygenic risk score (PRS) associations with WMHV, excluding APOE. AD-PRS in smooth muscle cells (SMCs) shows a significant association with increased WMHV.
Authors
- Hannah Chandler (ORCID: https://orcid.org/0000-0001-9936-9630)
- Valentina Escott‐Price (ORCID: https://orcid.org/0000-0003-1784-5483)
- Joshua Wheeler
- Kevin Murphy (ORCID: https://orcid.org/0000-0002-6516-313X)
- T. Lancaster (ORCID: https://orcid.org/0000-0003-1322-2449)
Institutions
- University of Bristol (GB)
- University of Bath (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1002/alz.14455
- Citations
- 3
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Wellcome
- Alzheimer's Society
- UK Dementia Research Institute
- Medical Research Council
- European Regional Development Fund