Potential Future Therapeutic Application of Mesenchymal Stem Cell-derived Exosomes in Ulcerative Colitis
Exosomes, a subclass of Extracellular Vesicles (EVs), are pivotal mediators of intercellular communication. Exosomes derived from Mesenchymal Stem Cells (MSCs) exhibit anti-inflammatory and immunomodulatory activities similar to that of their parental cells, which makes them a cell-free treatment strategy against Ulcerative Colitis (UC). Engineered MSC Exosomes (MSC-Exos) hold the potential to impart multifunctionality to MSCs and optimize their therapeutic effectiveness. This study provides a comprehensive overview of the research progress, mechanisms of action, and potential applications of MSC-Exos and engineered MSC-Exos in the treatment of UC.
Authors
- Huiting Qu (ORCID: https://orcid.org/0000-0003-2921-841X)
- Haibing Hua (ORCID: https://orcid.org/0000-0001-9346-9972)
- Chao Deng (ORCID: https://orcid.org/0000-0002-3672-0056)
- Jie He (ORCID: https://orcid.org/0000-0002-1210-3504)
- Shoukai He
- Chengfei Wang (ORCID: https://orcid.org/0000-0002-1572-2036)
- Youyi Liu (ORCID: https://orcid.org/0000-0003-1136-5630)
- Ting Liu (ORCID: https://orcid.org/0000-0002-7543-2591)
- Kewei Wang (ORCID: https://orcid.org/0000-0001-5869-2490)
Institutions
- Jiangnan University (CN)
- East China University of Science and Technology (CN)
- Jiangyin People's Hospital (CN)
- Wuxi Fourth People's Hospital (CN)
Publication Details
- Journal
- Current Stem Cell Research & Therapy
- Published
- 2024-12-31
- DOI
- https://doi.org/10.2174/011574888x340609241220053638
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.23