SGLT2 expression in human vasculature and heart correlates with low-grade inflammation and causes eNOS-NO/ROS imbalance
Low-grade inflammation is closely associated with SGLT2 expression in human vasculature and heart, and this response contributes to a feedforward mechanism with the AT1R/NADPH oxidase pathway to cause eNOS-NO/ROS imbalance.
Authors
- Michael Pieper (ORCID: https://orcid.org/0000-0003-1348-5927)
- Sin‐Hee Park (ORCID: https://orcid.org/0000-0002-7452-9615)
- Walaa Kamel Fakih (ORCID: https://orcid.org/0000-0002-1998-499X)
- Paola Algara‐Suárez
- Dal-Seong Gong (ORCID: https://orcid.org/0000-0002-0514-6776)
- Said Amissi (ORCID: https://orcid.org/0000-0002-3194-1183)
- Kensuke Matsushita (ORCID: https://orcid.org/0000-0002-3722-2921)
- Benjamin Marchandot (ORCID: https://orcid.org/0000-0001-7034-1466)
- Olivier Morel (ORCID: https://orcid.org/0000-0002-7295-3041)
- Jean‐Philippe Mazzucotelli
- Patrick Ohlmann (ORCID: https://orcid.org/0000-0002-8021-2737)
- Cyril Auger (ORCID: https://orcid.org/0000-0003-0695-3841)
- Valérie B. Schini‐Kerth (ORCID: https://orcid.org/0000-0001-9997-9287)
- Gilles Kauffenstein (ORCID: https://orcid.org/0000-0003-4994-8305)
- Laurence Jesel
- Nicolas Meyer
- Ali Mroueh (ORCID: https://orcid.org/0009-0001-7760-9741)
Institutions
- Boehringer Ingelheim (Germany) (DE)
- Hôpital Civil, Strasbourg (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1093/cvr/cvae257
- Citations
- 29
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 10.37