DAG-MAG-ΒHB: A Novel Ketone Diester Modulates NLRP3 Inflammasome Activation in Microglial Cells in Response to Beta-Amyloid and Low Glucose AD-like Conditions
In summary, DAG-MAG-ΒHB emerges as a promising treatment for neuroinflammatory conditions. It enhances cellular health under varying metabolic states and exhibits neuroprotective properties against low glucose conditions. These attributes indicate its potential as an effective component in managing neuroinflammatory diseases, addressing their complex progression.
Authors
- Daria Bortolotti (ORCID: https://orcid.org/0000-0003-4496-9561)
- Valentina Gentili (ORCID: https://orcid.org/0000-0003-4572-5497)
- Marco Narducci
- Latha Nagamani Dilliraj
- Giovanna Schiuma (ORCID: https://orcid.org/0000-0003-4652-5550)
- Matteo Marti (ORCID: https://orcid.org/0000-0001-8751-2882)
- Sabrina Rizzo (ORCID: https://orcid.org/0000-0002-9246-136X)
- Djidjell Lara (ORCID: https://orcid.org/0000-0002-3088-5466)
- Silvia Beltrami (ORCID: https://orcid.org/0000-0002-5923-9265)
- Roberta Rizzo (ORCID: https://orcid.org/0000-0001-9507-9126)
- Pier Paolo Giovannini (ORCID: https://orcid.org/0000-0002-7089-5466)
- Claudio Trapella (ORCID: https://orcid.org/0000-0002-6666-143X)
Institutions
- University of Ferrara (IT)
- Temple University, Japan (JP)
Publication Details
- Journal
- Nutrients
- Published
- 2024-12-31
- DOI
- https://doi.org/10.3390/nu17010149
- Citations
- 3
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- Ministero della Salute
- Università degli Studi di Ferrara