Detection of elevated succinate in brain during circulatory arrest in a piglet model: A <scp>3T <sup>1</sup>H MR</scp> spectroscopy study
Although spectrally overlapped and at sub-millimolar levels, elevated brain succinate can be reliably measured by dynamic MR spectroscopy at 3T. Noise dependent bias of the stronger overlapping signals did not impact the succinate measurement. Elevated succinate during circulatory arrest and its recovery after reperfusion was observed. This finding is consistent with earlier reports that correlate elevated succinate with ischemic-reperfusion injury.
Authors
- Frank L. Hanley
- Moussa Haidar (ORCID: https://orcid.org/0000-0001-6369-7616)
- Kenichi Okamura (ORCID: https://orcid.org/0000-0001-9205-3457)
- R. Kirk Riemer (ORCID: https://orcid.org/0000-0002-3054-9809)
- Daniel M. Spielman (ORCID: https://orcid.org/0000-0003-0838-6967)
- Yoshikazu Ono (ORCID: https://orcid.org/0009-0008-8041-5164)
- Masafumi Shibata (ORCID: https://orcid.org/0000-0001-8543-1317)
- Meng Gu
- Ralph E. Hurd (ORCID: https://orcid.org/0009-0000-7523-685X)
Institutions
- Stanford University (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1002/mrm.30414
- Citations
- 3
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- National Institutes of Health