From Challenges to Advancement for Bilayer Tablet Technology as Drug Delivery System

Bilayer tablet technology is in focus because it advantageous for combination therapy, for combining two different release profile and it gives patent novelty to existing dosage. Hence its advantages, challenges and applications need to be discuss. The objective of preparing a review article on bilayer tablets is multifaceted, aiming to cover challenges at formulation development to scaleup and opportunity for new product development by integrating it bilayer tablet technology with other formulation technology. With reference to all the electronic data it was found that bilayer tablets face many challenges from formulation development till commercial manufacturing like interfacial bonding strength, layer separation, effect of environment on bonding strength bilayer tablet. But all these challenges can be over come by resolving appropriate remedies like using plastic diluent in both layers, manufacturing bilayer tablet using appropriate bilayer tablet manufacturing machine, etc. going forward with this challenges bilayer tablets puts advantage like it can be use for combination therapy, for chronotherapeutic therapy, enhancing therapeutic activity by altering micro environmental pH etc. Review comprises the information of key challenges to be consider while selection of excipients during formulation development, challenges related to process of bilayer tablet manufacturing and manufacturing bilayer tablet by integrating it with novel drug delivery systems and processes for enhancing therapeutic effectiveness and patient compliance