Multisystem Inflammatory Syndrome in Children Versus Neonates: A Case Series

After several reports of a multisystem inflammatory disease in pediatric patients who had evidence of active or past infection with the novel coronavirus SARS-CoV-2, in May 2020, the Centers for Disease Control and Prevention (CDC) provided a case definition for this multisystem inflammatory syndrome in children (MIS-C). A similar presentation in neonates has been termed multisystem inflammatory syndrome in neonates (MIS-N). There is considerable overlap between clinical presentation for MIS-C and Kawasaki disease (KD) or atypical KD. Early diagnosis and treatment of these conditions are crucial to prevent serious complications. This case series describes three cases of MIS-C and MIS-N each and aims to provide evidence to advance the current understanding of these conditions.