Spanish Multicenter Megaprosthesis Study (MEGAPROT) on 816 Tumor Prostheses: Main Results

(1) Background: The use of tumor megaprostheses faces challenges, but the published series are typically small and offer limited solutions. Our aim was to compile a large series; describe patient profiles and surgical techniques; analyze prosthetic survival identifying factors affecting survival; and provide a basis for future subanalyses. (2) Methods: This is a retrospective observational multicenter study that included patients with a tumor megaprosthesis in any anatomical location. Demographic, etiologic, and surgical variables were analyzed. Data on complications and survival were also collected. (3) Results: Our series includes a total of 816 prostheses (585 primary, 181 revision, and 50 second revision). The patients’ mean age was 44.2 ± 20.8 years. Primary surgeries were performed on the femur (n = 404; 69.1%), tibia (n = 79; 13.5%), humerus (n = 74; 12.6%), pelvis (n = 20; 3.4%), and scapula (n = 4; 0.7%). Survival following primary surgery was 73.3% at 10 years. No statistically significant differences were found with respect to survival from primary surgery between males and females (p = 0.194), between the different etiologies (p = 0.540), or between the lower and the upper limb (p = 0.618). In contrast, statistically significant survival differences were found when the type of fixation was analyzed (p < 0.001). (4) Conclusions: This study analyzed one of the largest series of patients treated with tumor megaprostheses, demonstrating their acceptable survival and validating them as a treatment option for bone tumors.

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Journal
Prosthesis
Published
2024-12-28
DOI
https://doi.org/10.3390/prosthesis7010002
Primary Topic
Sarcoma Diagnosis and Treatment
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article
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article

Spanish Multicenter Megaprosthesis Study (MEGAPROT) on 816 Tumor Prostheses: Main Results

López León, F. González Lizán, Caleb Baz Figueroa, Oscar Cardona González et al.
Prosthesis
Sarcoma Diagnosis and Treatment
article

Spanish Multicenter Megaprosthesis Study (MEGAPROT) on 816 Tumor Prostheses: Main Results

López León, F. González Lizán, Caleb Baz Figueroa, Oscar Cardona González, María Pascual, Aida Orce, M. Sánchez, Amparo Godoy Montijano, Antonio Valcárcel Díaz, Jcr Perez, C. Garcés Zarzalejo, Víctor Manuel Zarzuela, Gabriela Cifuentes, Roberto García Maroto, L. Coll Mesa, Israel Pérez Muñoz, C. De la Calva Ceinos, Francisco Fernández Serrano, Icíar Arteagoitia, Pablo Puertas García-Sandoval, Paula González‐Rojo, J. S. León González, Juan Luis Cebrián Parra, Ana Maestre Peiró, Pau Machado Granados, Manuel Huaman Guerrero, I. Dorta, Isidro Gracia Alegría, Míriam Pérez, N. González, Pello Esnaloa, Álvaro Álvarez Garma, Libe Asua Mentxaka
article en

Abstract

(1) Background: The use of tumor megaprostheses faces challenges, but the published series are typically small and offer limited solutions. Our aim was to compile a large series; describe patient profiles and surgical techniques; analyze prosthetic survival identifying factors affecting survival; and provide a basis for future subanalyses. (2) Methods: This is a retrospective observational multicenter study that included patients with a tumor megaprosthesis in any anatomical location. Demographic, etiologic, and surgical variables were analyzed. Data on complications and survival were also collected. (3) Results: Our series includes a total of 816 prostheses (585 primary, 181 revision, and 50 second revision). The patients’ mean age was 44.2 ± 20.8 years. Primary surgeries were performed on the femur (n = 404; 69.1%), tibia (n = 79; 13.5%), humerus (n = 74; 12.6%), pelvis (n = 20; 3.4%), and scapula (n = 4; 0.7%). Survival following primary surgery was 73.3% at 10 years. No statistically significant differences were found with respect to survival from primary surgery between males and females (p = 0.194), between the different etiologies (p = 0.540), or between the lower and the upper limb (p = 0.618). In contrast, statistically significant survival differences were found when the type of fixation was analyzed (p < 0.001). (4) Conclusions: This study analyzed one of the largest series of patients treated with tumor megaprostheses, demonstrating their acceptable survival and validating them as a treatment option for bone tumors.

ProsthesisVol. 7(1)
Hospital de Sant Pau (ES), Bellvitge University Hospital (ES), Hospital Clínico San Carlos (ES), Hospital Universitari i Politècnic La Fe (ES), Hospital Universitario Nuestra Señora de Candelaria (ES), Marqués de Valdecilla University Hospital (ES), Biogipuzkoa Health Research Institute (ES), Hospital Universitario Virgen de las Nieves (ES), Hospital General Universitario De Valencia (ES), Hospital de Cruces (ES), Hospital Universitario Virgen de la Arrixaca (ES), Hospital Universitario Ramón y Cajal (ES)
Good health and well-being
Openalex Percentile: Top 56%
Sarcoma Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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