<i>Bacillus safensis</i> APC 4099 has broad-spectrum antimicrobial activity against both bacteria and fungi and produces several antimicrobial peptides, including the novel circular bacteriocin safencin E
The present article highlights the importance of the strain <i>Bacillus safensis</i> APC 4099 as a potential biocontrol agent. The strain possesses biosynthetic gene clusters coding for various antimicrobial peptides and secondary metabolites, including a novel circular bacteriocin, safencin E, and the bacteriocins pumilarin and plantazolicin. This diversity in the production of antimicrobial peptides renders the producer with broad-spectrum antimicrobial activity, ranging from gram-positive pathogenic and spoilage bacteria to spoilage molds. Considering that 1.3 billion tons of food appropriate for human consumption is lost or wasted annually, identifying strains or novel antimicrobial peptides capable of biopreservation is highly relevant. This strain and its bioactive compounds offer a solution to this global problem as biocontrol agents for food ecosystems against spoilage and pathogenic microbes.
Authors
- Colin Buttimer (ORCID: https://orcid.org/0000-0002-3361-8902)
- Jutta Wiese (ORCID: https://orcid.org/0000-0001-8511-5306)
- Colin Hill (ORCID: https://orcid.org/0000-0002-8527-1445)
- R. Paul Ross (ORCID: https://orcid.org/0000-0003-4876-8839)
- Aiswariya Deliephan
- Catherine Stanton (ORCID: https://orcid.org/0000-0002-6724-7011)
- Felipe Miceli de Farias (ORCID: https://orcid.org/0000-0001-5419-9922)
- Eleni Kamilari (ORCID: https://orcid.org/0000-0002-2473-9729)
- Paula M. O’Connor (ORCID: https://orcid.org/0000-0001-6462-2077)
- D.W. Hill
- Crystal N. Johnson (ORCID: https://orcid.org/0000-0002-7964-396X)
- Oxana Fursenko
Institutions
- Oklahoma State University (US)
- Kraft Heinz (United States) (US)
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- Kraft Heinz (United Kingdom) (GB)
- APC Microbiome Institute (IE)
- Oklahoma State University Center for Health Sciences (US)
Publication Details
- Journal
- Applied and Environmental Microbiology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1128/aem.01942-24
- Citations
- 11
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 3.83
Funders
- European Commission
- Science Foundation Ireland