Formulation and In-Vitro Assessment of Torsemide -Loaded Microspheres for Controlled Drug Delivery

ABSTRACT: The present work aimed at formulation development and evaluation of Torsemide (TOR) microspheres. The loop diuretic TOR is used to treat congestive heart failure and edema. Due to its short half-life of two to three hours, weak basicity, and high solubility, TOR is released rapidly and does not provide sustained drug release. To achieve controlled drug release at a predetermined rate, TOR was prepared into microspheres. A total of 12 formulations were prepared by combining Sodium alginate with varying proportions of the polymers Eudragit RL100 and Hydroxy propyl methyl cellulose K15 (HPMC K15) by the ionotropic gelation technique and evaluated for micromeritic properties, percentage yield, drug entrapment efficiencies and in- vitro dissolution studies. Stability tests were performed out on the optimized formulation. Particle size of formulations was within acceptable limits, with percentage yields ranging from 80.5±0.012 to 95.3±0.028 and entrapment efficiencies from 72.5±0.024 to 86.8±0.020. Formulation F6 exhibited the highest drug release of 100% in a controlled manner, thus it was considered the optimized formulation and no stability issues were found.