Pediatric T-lymphoblastic Leukemia With an Entirely Mature Immunophenotype: A Prompt and Challenging Diagnosis
Children with T-ALL/LBL require prompt diagnosis and treatment. Flow cytometric analysis of T-lineage and immaturity markers usually leads to a straightforward diagnosis. However, rare cases of T-ALL expressing bright CD45 and lacking expression of immature markers can be a diagnostic conundrum and difficult to differentiate from mature T-cell lymphomas lacking surface CD3 expression or aberrantly expressing immature markers, which affects treatment decisions and prognosis. Here, we summarize the clinical, pathologic, and genetic features of 3 pediatric T-ALL cases with an entirely mature immunophenotype.
Authors
- Reuven J. Schore (ORCID: https://orcid.org/0000-0002-1582-2168)
- Birte Wistinghausen (ORCID: https://orcid.org/0000-0002-2874-121X)
- Shana Jacobs (ORCID: https://orcid.org/0000-0002-0678-0621)
- Jinjun Cheng (ORCID: https://orcid.org/0000-0001-8930-7903)
- Keri Toner (ORCID: https://orcid.org/0000-0002-9324-7314)
- Yannan Wang (ORCID: https://orcid.org/0000-0001-7248-4954)
- Shunyou Gong (ORCID: https://orcid.org/0000-0002-7883-4879)
Institutions
- Lurie Children's Hospital (US)
- George Washington University (US)
- Center for Cancer and Blood Disorders (US)
Publication Details
- Journal
- Journal of Pediatric Hematology/Oncology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1097/mph.0000000000002967
- Citations
- 1
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.54