Evaluation of Wound Healing Potential of Hydnocarpus wightiana Seed Extract in Alloxan-Induced Diabetic Rats

ABSTRACT: Medicinal plants play an important role in Phyto-pharmacological research and the new drug development process. These new drugs are used to treat illnesses and their various illnesses. Hydnocarpus wightiana is one of the most important drugs traditionally used for treating the seas and wounds. During the literature survey, no significant data was found on the wound-healing process of Hydnocarpus wightiana in diabetic rats. Thus, the current study examined the wound-healing potential of Hydnocarpus wightiana seed extract in Alloxan-monohydrate-induced diabetic rats. The crude extract was carried out using ethanol with the help of the Soxhlet apparatus by hot inoculation method. Diabetes was induced by using a single dose of streptozotocin (50mg/kg). The wound healing potential was evaluated with the help of two models, including the excision wound model and the incision wound model. In this study, topical ointment was prepared in three different concentrations: 1%, 2%, & 4%. Various parameters were evaluated during this study, i.e., contraction rate, wound index, period of epithelization, and tensile strength. Our study concluded that the 4% w/w in ointment preparation of ethanolic Hydnocarpus wightiana extract showed better and faster wound healing activity as compared to the 1% and 2% w/w treated groups.