Neuroprotective Activity of Flavonoids from Peperomia pellucida by Invitro and Insilico Studies

Introduction: One of the neurodegenerative disorders that causes irreversible mild cognitive impairment is Alzheimer's disease(AD). As AD becomes more prevalent, the need for the development of innovative technologies and medications to prevent and treat neurodegeneration becomes increasingly critical. The plant Peperomia pellucida possesses neuroprotective properties. Material & Methods: Invitro Acetylcholinesterase Inhibitory Activity performed in Peperomia pellucida extract and insilico evaluations conducted using online tools such as Autodock, PASS, Swiss ADME, and ProTox-II. Result: Peperomia pellucida ethanolic extract inhibits cholinesterase more effectively than other extracts, according to the present invitro investigation. Acacetin, Isovitexin, and Apigenin are the significant flavonoids found in Peperomia pellucida. The effectiveness of these flavonoids against Alzheimer's disease was proven by insilico and toxicity profile studies. Conclusion: Acacetin and Apigenin exhibit comparable docking scores to Isovitexin, whereas the former demonstrates superior results in ADME parameters and safety. The potential therapeutic applications of flavonoid constituents derived from Peperomia pellucida for Alzheimer's disease are underscored in this work.