DEVELOPMENT AND IN VITRO EVALUATION OF OLEUM ROSMARINI BASED TOPICAL EMULGEL FORMULATION FOR RHEUMATIC DISEASE

Objective: In this study, it was aimed to develop a topical emulgel formulation from o/w type emulsions containing Oleum rosmarini, to be used in the treatment of rheumatoid arthritis. Material and Method: Carbopol 996 and HPMC were used as the water phase and Oleum rosmarini was used as oil phase in the emulsion combinations containing oil, surfactant, copolymer and plasticizer at different rates over different polymer concentrations, to select the appropriate formulation with in vitro formulation studies. Organoleptic controls of the selected formulations were made and characterizations were made in terms of pH, texture profile analysis, rheology evaluation and thermodynamic stability. Result and Discussion: The pH value of the optimized formulations was in the range of 5.5-6.5. The formulations were obtained homogeneously, and no phase separation was observed. It has been observed that the emulgels provide suitable viscosity, flow properties, mechanical properties and have high stability for topical application.