Development & Formulation of Taxifolin Loaded Niosomes for its Anticancer Effect on MCF-7 Breast Cancer

In order to increase Taxifolin's solubility and bioavailability, this study set out to create and assess niosomes of Taxifolin powder by the thin film hydration approach. A nonionic surfactant called span 60 and a membrane stabiliser called cholesterol were utilised. Particle size distribution, zeta potential, and light scattering analysis were all examined. Niosomes demonstrated a mean particle size between 106.5± 7.42 nm and 115.8 ±11.61 nm, with particle size increasing as the surfactant and cholesterol molar ratios were raised. The percentage yield was found to be in range 44 ± 0.235% to 81 ± 0.216%. The optimized batch (FC6) had zeta potential of -27.7 ± 2.37 mV and 92.78 ± 3.14 %entrapment efficiency. Taxifolin loaded niosomes demonstrated sustained release of Taxifolin.The anticancer potential of compound was evaluated using an in vitro cytotoxicity assay on MCF-7 cell lines. Finally, associated to free Taxifolin, cytotoxic impact of Taxifolin loaded niosomes on MCF-7 cell line was found to be substantially improved by the MTT assay. Result demonstrated that solubility and bioavailability of naturally derived Taxifolin phytochemicals can be increase by loading it into niosomes, thus enhance their anticancer efficacy.