Formulation and Evaluation of Docetaxel Floating Microspheres

This study sought to create floating microspheres containing Docetaxel, a cutting-edge anti-mitotic chemotherapeutic medication frequently used in the treatment of breast, ovarian, and non-small cell lung malignancies. The experimental results demonstrated that FT-IR evaluation exhibited no significant peak shifts, suggesting that the drug within the microspheres is stable in the short term. Biocompatible polymers, that include chitosan and albumin, were incorporated for the development of microspheres, both of which generated a great deal of drug entrapment and sufficient yield. All formulations have acceptable flow characteristics to allow for simple capsule loading. Furthermore, raising its polymer concentration resulted in an enormous decrease in cumulative drug release percentage. The formulations D7 is best fitted in various kinetic models