Design and Evaluation of Fast Dissolving Tablets of Anti-Hypertensive Poorly Soluble Drug through 23 Factorial Designs

The purpose of this study was to improve the anti-hypertensive effect of telmisartan fast-dissolving tablets by formulating them with a synthetic superdisintegrant. The effects of three factors—SH [A], SSG [B], and CCS [C] on dependent variables like the in vitro method, water absorption, and percent drug release at 10 minutes were investigated in this survey using three factors in a two-level (23) factorial design. The production of starch hyaluronate, a fine, freely-flowing crystalline powder, was accomplished by the esterification process. The ester bond between starch and hyaluronic acid was confirmed by FTIR analysis, and starch hyaluronate did not interact with the medication in the DSC testing. The formulation with the shortest disintegration time, TF2, took only 24±0.2 seconds to complete. In ten minutes, 93.68 ±1.32% of the medicines from the optimal composition had dissolved. Moreover, a mixture containing a 5% level of starch hyaluronate was refined and could be utilized in creating quickly dissolving tablets. This formula also improved clinical compliance during the effective treatment of hypertension. The optimized composition was able to achieve a low concentration of a novel synthetic super disintegrate in a short amount of time.