Placental extracellular vesicles induce ovarian tumour cell death in an ex vivo explant model: Possible therapeutic potential
Our study demonstrated that placental EVs could induce necrosis in ovarian tumour explants. Increased levels of apoptosis and senescence-associated proteins and miRNAs could contribute to this change in ovarian tumour cell phenotype after exposure to placental EVs.
Authors
- Ye Shen (ORCID: https://orcid.org/0000-0003-0874-4285)
- Min Zhao (ORCID: https://orcid.org/0000-0002-8752-7221)
- Yongxiang Yin (ORCID: https://orcid.org/0000-0002-2180-5647)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-0896-0001)
- Yunhui Tang (ORCID: https://orcid.org/0000-0003-1191-4679)
- Qi Chen (ORCID: https://orcid.org/0000-0001-5894-6331)
- Xinyi Sun (ORCID: https://orcid.org/0000-0003-4403-0431)
- Jiayi Wan
- Lawrence W. Chamley (ORCID: https://orcid.org/0000-0002-7501-1340)
Institutions
- Jiangnan University (CN)
- University of Auckland (NZ)
- Auckland University of Technology (NZ)
- Wuxi No.2 People's Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Placenta
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1016/j.placenta.2024.12.028
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.23