Evaluation of Hypo-glycemic and Anti-oxidant Potential of Caesalpinia sappan Leave in STZ Induced Diabetic Rats

In southern Asia, including India, Sri Lanka, and other countries, the stem bark, root, and leaves of Caesalpinia Sappan (Fabaceae) have been utilized in traditional medical systems to cure diabetes and numerous other illnesses. The hypoglycemic and hypolipidemic potential of this valued plant's leaves and bark, however, has not yet been proven by science. The current study's objective is to assess the hypoglycemic and hypolipidemic effects of Caesalpinia Sappan leaf ethanol extracts. Hydro-alcoholic extracts in dose 200mg/kg of Caesalpinia Sappan leaves (CSL) was evaluated for hypo-glycemic effect by In vitro α-amylase & α-glucosidase anti-diabetic potential similarly in vivo by using animals for 21 days in addition to the hypolipidemic potential in rats with diabetes induced by streptozotocin.The α-amylase & α-glucosidase inhibition activity was enhanced with enhanced in the concentration of extract. On administration of CSL it restored the body and organs weight. Similarly When CSL extracts were given to diabetic animal as supplements; the levels of GlyHb and plasma glucose were recovered, while insulin, C-peptide, and Hb parameters increased. In the current investigation, MDA levels were shown to be elevated; however, these levels were considerably decreased on the addition of glibenclamide and the hydro-ethanolic extract of CSL.The presence of active principles in the extract and fractions could be the cause of the observed outcome. In comparison to glibenclemide, the usual medication, the results demonstrated the potential effects of Caesalpinia Sappan leaves extract as hypoglycemic and anti-hyperlipidemic in a dose-dependent manner. Scientific evidence supports the traditional usage of this substance as an anti-diabetic.