Potential role of liver-resident CD3+ macrophages in HBV clearance in a mouse hepatitis B model
The liver is a special organ with unique immune characteristics and tolerance to foodborne antigens. Chronic infections can develop in newborns after exposure to HBV; however, acute infections usually occur in adults, indicating that immune cells in the liver tissue microenvironment can also effectively fight against the virus. Nevertheless, the mechanisms involved in acute HBV infection have rarely been studied. In this study, we identified a macrophage population with both T cell and macrophage characteristics in the livers of acute HBV model mice and revealed that these macrophages play important roles in HBV clearance. Moreover, we confirmed that this population is derived from macrophages in the presence of virus-specific T cells and antibodies. This finding highlights the complexity of antiviral immune responses in liver microenvironments.
Authors
- Cong Wang (ORCID: https://orcid.org/0000-0001-6684-6891)
- Zhong Fang (ORCID: https://orcid.org/0000-0002-7703-8686)
- Kuangjie Zhao
- Bisheng Shi
- Maya Kozlowski (ORCID: https://orcid.org/0000-0002-6550-1725)
- Zhenghong Yuan (ORCID: https://orcid.org/0000-0003-0268-4891)
- Xiaonan Zhang (ORCID: https://orcid.org/0000-0002-1286-7280)
- Yaming Li (ORCID: https://orcid.org/0000-0001-5627-229X)
- Min Wu (ORCID: https://orcid.org/0000-0002-4784-226X)
- Xiaohui Zhou (ORCID: https://orcid.org/0000-0001-7491-628X)
- Wenjing Zai (ORCID: https://orcid.org/0000-0003-2550-331X)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101323
- Citations
- 3
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- National Key Research and Development Program of China