The A–Z of age-related dermatological diseases

Skin ageing is an inevitable process influenced by both intrinsic and extrinsic factors. Intrinsic aging leads to thinner, drier and less elastic skin with fine wrinkles, while extrinsic factors such as sun exposure, smoking and environmental stresses amplify these changes. Photo-ageing, in particular, causes deep wrinkles, uneven pigmentation and increases the risk of skin cancers. Age-related alterations in skin structure and function include thinning of the epidermis, reduced collagen and elastin and changes in fat distribution, all of which compromise the skin's barrier and mechanical properties. These changes not only increase the susceptibility to conditions such as xerosis, fungal infections and atopic dermatitis but also carry psychological implications. Interestingly, atopic dermatitis, often associated with childhood, has a secondary peak in older adults and may be linked to neurodegenerative conditions such as Alzheimer's disease. This article explores the interplay between skin aging, dermatological diseases, and their broader physical and emotional impacts.