DYNAMICS OF CHANGES IN THE CELLULAR COMPOSITION OF THE FOCUS OF CHRONIC INFLAMMATION WITH DABIGATRAN ETEXILATE ADMINISTRATION

Inflammation is a natural defense reaction of the body to infections and injuries, aimed at eliminating pathogens and promoting tissue repair to maintain homeostasis. It is triggered in response to pathogen- or damage-associated molecular patterns, initiating a complex process that involves the recruitment and activation of both hematopoietic and non-hematopoietic cells, such as neutrophils, macrophages, fibroblasts, and others. These cells interact to coordinate tissue repair and regeneration. When this process is well-controlled, tissue structure is properly restored. However, if inflammation becomes chronic or uncontrolled, pathological fibrosis can develop, disrupting tissue function and potentially leading to organ failure or death. Therefore, healing processes must be strictly regulated to maintain normal tissue function. Aim of the study: to investigate the dynamics of changes in the cellular composition of the focus of secondary chronic carrageenan-induced inflammation with the administration of the thrombin inhibitor dabigatran etexilate. Material and methods. The study was conducted on 72 adult male WAG rats, weighing 180-200 g. The model of inflammation was secondary chronic aseptic inflammation induced by intramuscular injection of 10 mg λ-carrageenan into the right thigh area. The thrombin inhibitor dabigatran etexilate was administered intragastrically via gavage at a dose of 15 mg/kg/day throughout the experiment. The dynamics of cellular composition changes in the focus of inflammation were studied on days 1, 7, 14, 21, and 28 of the experiment. Results. The study of the dynamics of cellular composition changes in the focus of secondary chronic carrageenan-induced inflammation with the administration of the thrombin inhibitor dabigatran etexilate confirmed its ability to influence the course of the inflammatory process. Peaks in basophil and eosinophil accumulation were observed on day 1, followed by a gradual decrease in their numbers, with predominantcomposition changes in the focus of inflammation were studied on days 1, 7, 14, 21, and 28 of the experiment. Results. The study of the dynamics of cellular composition changes in the focus of secondary chronic carrageenan-induced inflammation with the administration of the thrombin inhibitor dabigatran etexilate confirmed its ability to influence the course of the inflammatory process. Peaks in basophil and eosinophil accumulation were observed on day 1, followed by a gradual decrease in their numbers, with predominant.