Histologic and Endoscopic Findings Are Highly Correlated in a Prospective Cohort of Patients With Inflammatory Bowel Diseases
In a real-world setting, endoscopic inflammation predicted histologic inflammation with high accuracy. In patients with a Rutgeerts score of i0, microscopic inflammation in neo-TI biopsies did not predict more aggressive disease behavior over the next 4 years. These results have implications for the design of clinical trials, suggesting the use of endoscopic healing as an endpoint.
Authors
- David H. Kerman
- Joao M. Serigado
- Federica Di Vincenzo (ORCID: https://orcid.org/0000-0002-5347-7641)
- Jonathan England (ORCID: https://orcid.org/0000-0002-6330-3688)
- Maria A. Quintero (ORCID: https://orcid.org/0000-0003-2249-6564)
- Amar R. Deshpande (ORCID: https://orcid.org/0009-0007-0848-7158)
- Oriana M. Damas (ORCID: https://orcid.org/0000-0002-9256-190X)
- Tulay Koru‐Sengul (ORCID: https://orcid.org/0000-0003-0974-8405)
- Julio Poveda (ORCID: https://orcid.org/0009-0003-3075-0849)
- Maria T. Abreu
- Rose Killian
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Cleveland Clinic (US)
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1093/ecco-jcc/jjae141
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00