FTO-mediated regulation of Kupffer cell polarization and interleukin-6 secretion promotes biliary epithelial cell proliferation in intrahepatic bile duct stones
FTO plays a critical role in IBDS by promoting the M2 polarization of KCs, which leads to increased IL-6 secretion and induced pathological HiBEC proliferation. Targeting FTO may represent a novel therapeutic strategy for managing IBDS and preventing disease progression.
Authors
- Hui Peng (ORCID: https://orcid.org/0000-0003-0536-0913)
- Fuhai Zhou (ORCID: https://orcid.org/0000-0002-3764-3937)
- Qingsheng Yu (ORCID: https://orcid.org/0000-0001-8924-8050)
- Ziyi Li (ORCID: https://orcid.org/0000-0001-8815-5696)
- Lixiang Li (ORCID: https://orcid.org/0000-0001-9949-8731)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
- Qujiang People's Hospital (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2024-12-31
- DOI
- https://doi.org/10.25259/cytojournal_193_2024
- Citations
- 3
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.72