Loss of Mfn1 but not Mfn2 enhances adipogenesis
Loss of Mfn1 but not Mfn2 in cultured pre-adipocyte models is pro-adipogenic. This suggests distinct, non-redundant roles for the two mitofusin orthologues in adipocyte differentiation.
Authors
- Luis Carlos Tábara (ORCID: https://orcid.org/0000-0001-7684-3811)
- Anna Álvarez-Guaita (ORCID: https://orcid.org/0000-0002-9248-2275)
- Daniel J. Fazakerley (ORCID: https://orcid.org/0000-0001-8241-2903)
- David B. Savage (ORCID: https://orcid.org/0000-0002-7857-7032)
- Jake P. Mann (ORCID: https://orcid.org/0000-0002-4711-9215)
- Afreen Haider (ORCID: https://orcid.org/0000-0003-4768-0499)
- Satish Patel (ORCID: https://orcid.org/0000-0002-5345-8942)
- James E. N. Minchin (ORCID: https://orcid.org/0000-0003-2316-1010)
- Koini Lim (ORCID: https://orcid.org/0000-0003-1526-4917)
- Fabio Scurria
- Julien Prudent (ORCID: https://orcid.org/0000-0003-3821-6088)
- Panna Tandon (ORCID: https://orcid.org/0000-0002-9115-4173)
- Robert K. Semple (ORCID: https://orcid.org/0000-0001-6539-3069)
- Liang Dong (ORCID: https://orcid.org/0000-0002-4673-1816)
- Stephen O’Rahilly S.
- Pushpa Pushpa
Institutions
- University of Cambridge (GB)
- Wellcome/MRC Institute of Metabolic Science (GB)
- Institute of Genetics and Cancer (GB)
- MRC Mitochondrial Biology Unit (GB)
- Wellcome Trust (GB)
- Medical Research Council (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1371/journal.pone.0306243
- Citations
- 2
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- NIHR Cambridge Biomedical Research Centre