Antibiotic Sensitivity of the Staphylococcus aureus and Streptococcus pyogenes Isolated from Pediatric Skin Infections

In a study conducted at Al-Diwaniyah Hospital between February 2024 and September 2024, samples were collected from various anatomical sites including the face, hands, feet, genital area, and other parts, the antimicrobial efficacy of various antibiotics against Staphylococcus and Streptococcus species was investigated, focusing on eleven different antibiotics. For Staphylococcus, the results indicate notable variations in minimum inhibitory concentrations (MICs) across the antibiotics tested. Among the aminoglycosides, Amikacin exhibited a MIC of 9.5 ± 1.5, while Gentamicin showed a slightly higher MIC of 14.3 ± 1.8. Fluoroquinolones like Ciprofloxacin demonstrated an MIC of 16.7 ± 2.3, with Rifampicin displaying a relatively higher MIC of 20.56 ± 3.67. The combination sulfonamide Sulfamethoxazole-Trimethoprim and Nitrofurantoin exhibited MICs of 13.83 ± 2.11 and 15.76 ± 2.13, respectively. Erythromycin and Tetracycline displayed ineffective results with MICs of 0. The weakest value of the geometric mean determined for there was 6.83 ± 1.23 for Penicillin and the highest value was for Vancomycin 8.9 ± 3.69. While the minimum inhibitory concentration values for Streptococcus species were in the same range for Staphylococcus species with some few differences. For example, Amikacin had an MIC of 10.2 ± 1.3 for Streptococcus. The other results were a ciprofloxacin MIC of 17.5 ± 2.1, an aminoglycoside gentamicin MIC of 13.8 ± 1.2 and a rifampicin which presented an MIC of 21.4 ± 3.1. Treating infected skin lesions with Staphylococcus aureus and Streptococcus pyogenes with targeted antibiotic therapy based on sensitivity testing directed comparison to empiric therapy is conspicuously important for achievement of good clinical result.