Tilted Fiber Bragg Grating for Rapid Clinical Detection of Platinum Ion

In this paper, we have developed a highly sensitive and practical sensor for platinum ions, which holds significant promise for clinical cancer diagnosis and pharmaceutical development. The sensor utilizes tilted fiber Bragg grating surface plasmon resonance as its core sensing technology, integrating it with DNA-targeted biomolecule probes to enable precise target-specific capture. By detecting various concentrations of platinum ions, we have successfully demonstrated that the sensor's detection range and minimum detection concentration adequately meet the requirements for clinical platinum ion detection, offering an effective technical solution for implementing long-term point-of-care testing of platinum drugs.