Early Myocardial Strain Reduction and miR-122-5p Elevation Associated with Interstitial Fibrosis in Anthracycline-Induced Cardiotoxicity
A notable percentage of low-risk patients exhibited cardiac strain reduction due to cardiotoxicity. Epirubicin treatment caused structural heart changes in rats, highlighting miR-122-5p as a potential fibrosis marker that correlated with echocardiographic parameters.
Authors
- Antonio Ordóñez (ORCID: https://orcid.org/0000-0002-4344-8660)
- Tarik Smani (ORCID: https://orcid.org/0000-0002-1877-7438)
- María de Regla Caballero Valderrama (ORCID: https://orcid.org/0000-0003-2958-337X)
- Miriam Echevarrı́a (ORCID: https://orcid.org/0000-0002-4758-9428)
- José López‐Haldón (ORCID: https://orcid.org/0000-0002-6434-3614)
- Eva Calderón-Sánchez (ORCID: https://orcid.org/0000-0002-9599-3513)
- Francisco Javier Salvador-Bofill
- E Bevilacqua (ORCID: https://orcid.org/0000-0003-1434-8158)
Institutions
- Instituto de Biomedicina de Sevilla (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-12-27
- DOI
- https://doi.org/10.3390/biomedicines13010045
- Citations
- 2
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Sociedad Española de Cardiología
- Junta de Andalucía
- Agencia Estatal de Investigación