Review and External Evaluation of Population Pharmacokinetic Models for Vedolizumab in Patients with Inflammatory Bowel Disease: Assessing Predictive Performance and Clinical Applicability
None of the published models satisfied the combined criteria (MDPE, MAPE, percentages of prediction error within ±20% and ±30%), rendering them unsuitable for a priori predictions. However, two models demonstrated better suitability for simulation-based applications.
Authors
- Tamara Knežević Ivanovski
- Katarina M. Vučićević (ORCID: https://orcid.org/0000-0001-9676-5785)
- O Odanovic
- Ana Homšek (ORCID: https://orcid.org/0000-0002-0127-5538)
- Marija Jovanović (ORCID: https://orcid.org/0000-0001-6267-7509)
- Srdjan Marković (ORCID: https://orcid.org/0000-0001-5009-5704)
- Đorđe Kralj
- Petar Svorcan (ORCID: https://orcid.org/0000-0001-7627-812X)
Institutions
- University of Belgrade (RS)
- Kliničko Bolnički Centar Zvezdara (RS)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-12-27
- DOI
- https://doi.org/10.3390/biomedicines13010043
- Citations
- 2
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- Science Fund of the Republic of Serbia