Proceedings of the Inter-Disciplinary Conclave (IDC-2024) during the NCRM NICHE 2024

Intoductionve a broad spectrum of biological properties, reflecting their usefulness for clinical applications, e.g., in hepatic [1] and cardiovascular disease [2] or for bone regeneration [3] .A positive impact of MSCs cultivated in vitro has been demonstrated on the suppression of (auto)immunological [4] and inflammatory [5] responses and on the regeneration of damaged tissues [6] .ation of bone through tissue engineering (TE) can avoid autologous bone grafts [3,7] , which are limited by availability, geometry, donor site morbidity, and cost [8] .TE combines progenitor or stem cells, growth factors and biocompatible, three-dimensional scaffolds (e.g., hydroxyapatite or -tricalcium phosphate) to produce new bone when implanted into critical size defects [7,9] .While several clinical studies report beneficial effects when injecting "bone marrow concentrate aspirates" rich in MSCs in cases of osteoarthritis [10,11] or