Genetic Insights Into the Role of Cathepsins in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis: Evidence From Mendelian Randomization Study

Our study provides new genetic insights into the role of cathepsin H in AD and cathepsin B in PD. However, our findings need to be further validated in a wider population, and future research should explore the potential mechanisms of cathepsins in these diseases in order to provide a basis for the development of new therapeutic strategies.

Authors

Publication Details

Journal
Brain and Behavior
Published
2024-12-31
DOI
https://doi.org/10.1002/brb3.70207
Citations
4
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
1.31
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article

Genetic Insights Into the Role of Cathepsins in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis: Evidence From Mendelian Randomization Study

Hua Xue, Yaxin Li, Yan‐Hong Jiang, Wenhui Fan
4 citations
Brain and Behavior
Alzheimer's disease research and treatments
1.31
article

Genetic Insights Into the Role of Cathepsins in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis: Evidence From Mendelian Randomization Study

Hua Xue, Yaxin Li, Yan‐Hong Jiang, Wenhui Fan
article en
4 citations

Abstract

Our study provides new genetic insights into the role of cathepsin H in AD and cathepsin B in PD. However, our findings need to be further validated in a wider population, and future research should explore the potential mechanisms of cathepsins in these diseases in order to provide a basis for the development of new therapeutic strategies.

Brain and BehaviorVol. 15(1)
Good health and well-being
Openalex Percentile: Top 18%
Alzheimer's disease research and treatments
1.31
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