Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer's disease, and primary age‐related tauopathy hippocampi
Alzheimer's disease neuropathologic change (ADNC), possible primary age-related tauopathy (PART), definite PART, and chronic traumatic encephalopathy (CTE) can be differentiated based on the proteomic composition of their neurofibrillary tangle (NFT)- and non-NFT-bearing neurons. The proteome of these NFT- and non-NFT-bearing neurons is largely correlated with the presence or absence of amyloid beta (Aβ). Neurons in CTE and definite PART (Aβ-independent pathologies) share numerous proteomic similarities that distinguish them from ADNC and possible PART (Aβ-positive pathologies).
Authors
- Justin Kauffman
- Susan K. Rohde (ORCID: https://orcid.org/0000-0002-9985-9645)
- Kevin Clare (ORCID: https://orcid.org/0000-0003-0300-6080)
- Elena V. Daoud (ORCID: https://orcid.org/0000-0001-8840-5106)
- Kevin F. Bieniek (ORCID: https://orcid.org/0000-0003-4922-864X)
- Carolina Maldonado‐Díaz (ORCID: https://orcid.org/0000-0002-4185-7102)
- Charles L. White (ORCID: https://orcid.org/0000-0002-3870-2804)
- Kurt Farrell (ORCID: https://orcid.org/0000-0001-6955-7278)
- Adam O. Goldstein (ORCID: https://orcid.org/0000-0002-0664-235X)
- Enna Selmanovic (ORCID: https://orcid.org/0000-0002-5350-4566)
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Emma L Thorn (ORCID: https://orcid.org/0009-0007-3875-7542)
- Ann Carolyn McKee (ORCID: https://orcid.org/0000-0003-2961-7488)
- Tiffany F. Kautz (ORCID: https://orcid.org/0000-0001-7680-4708)
- Miranda E. Orr (ORCID: https://orcid.org/0000-0002-0418-2724)
- Connie Slocum
- Leyla Canbeldek
- Thomas Wısnıewskı (ORCID: https://orcid.org/0000-0002-3379-8966)
- Michael L. Alosco (ORCID: https://orcid.org/0000-0002-8113-8428)
- Daniel Koenigsberg (ORCID: https://orcid.org/0009-0009-3861-8192)
- Timothy E. Richardson (ORCID: https://orcid.org/0000-0001-7068-5517)
- Satomi Hiya
- Eleanor Drummond (ORCID: https://orcid.org/0000-0002-5466-4609)
- John F. Crary (ORCID: https://orcid.org/0000-0002-0556-293X)
- Lakshmi Shree Kulumani Mahadevan (ORCID: https://orcid.org/0000-0003-4701-252X)
- Gabriel A. Marx
- Jorge Samanamud (ORCID: https://orcid.org/0000-0003-2436-7539)
- Jamie M. Walker (ORCID: https://orcid.org/0000-0003-1263-7394)
- Alexander J. Ehrenberg (ORCID: https://orcid.org/0000-0003-4334-9424)
- Timothy C. Orr
- Alison Goate (ORCID: https://orcid.org/0000-0002-0576-2472)
- Raquel T. Yokoda (ORCID: https://orcid.org/0000-0003-1780-4446)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Claudia De Sanctis (ORCID: https://orcid.org/0000-0002-9318-7323)
- Nicholas Scibetta
- Robina Afzal
- Thomas D. Christie
- Victoria Flores‐Almazan
Institutions
- Boston University (US)
- The University of Sydney (AU)
- Albert Einstein College of Medicine (US)
- Allen Institute for Brain Science (US)
- Montefiore Medical Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- VA Boston Healthcare System (US)
- VA New England Healthcare System (US)
- St. Louis VA Medical Center (US)
- University Memory and Aging Center (US)
- Amsterdam Neuroscience (NL)
- Innovative Genomics Institute (US)
- Institute for Neurodegenerative Disorders (US)
- New York University (US)
- Vrije Universiteit Amsterdam (NL)
- The University of Texas Southwestern Medical Center (US)
- University of California, Berkeley (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1002/alz.14487
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- U.S. Department of Veterans Affairs
- Parkinson's Disease Foundation
- Cure Alzheimer's Fund
- Rainwater Charitable Foundation
- Texas Alzheimer's Research and Care Consortium
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke