Synaptic alterations in pyramidal cells following genetic manipulation of neuronal excitability in monkey prefrontal cortex
The primate dorsolateral prefrontal cortex (DLPFC) displays unique in vivo activity patterns, but how in vivo activity regulates DLPFC pyramidal neuron (PN) properties remains unclear. We assessed the effects of in vivo Kir2.1 overexpression, a genetic silencing tool, on synapses in monkey DLPFC PNs. We show for the first time that recombinant ion channel expression successfully modifies the excitability of primate cortex neurons, producing effects on synaptic properties apparently different from those in the rodent cortex.
Authors
- Takeaki Miyamae (ORCID: https://orcid.org/0000-0001-8917-9542)
- Guillermo González‐Burgos (ORCID: https://orcid.org/0000-0002-1650-8111)
- Mingshan Xue (ORCID: https://orcid.org/0000-0003-1463-8884)
- Kenneth N. Fish (ORCID: https://orcid.org/0000-0003-1774-3815)
- Zhao‐Lin Cai (ORCID: https://orcid.org/0000-0003-4034-2884)
- Yosuke Nishihata
- William R. Stauffer (ORCID: https://orcid.org/0000-0003-1031-8824)
- Dominique Arion
- David A. Lewis (ORCID: https://orcid.org/0000-0002-3225-6778)
- Kirsten Wade
- Olga L Krimer
Institutions
- University of Pittsburgh (US)
- Baylor College of Medicine (US)
- Neurological Research Institute (US)
- Texas Children's Hospital (US)
Publication Details
- Journal
- Journal of Neurophysiology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1152/jn.00326.2024
- Primary Topic
- Neural dynamics and brain function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Institutes of Health
- Directorate for Biological Sciences
- National Institute of Mental Health