Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis
Our study identified daidzein as an effective component that ameliorated lovastatin-induced skeletal muscle atrophy through blockage of abnormal activation of AMPK/FOXO3a and transcriptional activation of genes encoding downstream muscle-related proteins. Our results also highlighted the therapeutic potential by regulating the AMPK/FOXO3a axis in management of statin-induced myotoxicity.
Authors
- Hua Yang (ORCID: https://orcid.org/0000-0002-4876-4072)
- Hao Zeng (ORCID: https://orcid.org/0000-0002-2061-6350)
- Keke Wang (ORCID: https://orcid.org/0000-0003-4428-0465)
Institutions
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s13020-024-01034-5
- Citations
- 3
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- State Key Laboratory of Natural Medicines
- National Key Research and Development Program of China