Pathomorphological approach on canine sebaceous tumors

Sebaceous neoplasms are among the most frequently observed skin tumors in dogs. The histological classification of sebaceous glands (including Meibomian glands) is made according to sebocyte and basaloid reserve cell components. In this study aiming to examine sebaceous tumors in detail, 28 biopsies diagnosed with sebaceous neoplasia, including Meibomian gland neoplasia, were examined and diagnosed as adenoma (n:9), epithelioma (n:12), and carcinoma (n:7). Histopathologically; cell ratios (sebaceous/basal), appearance (diffuse/multilobular), presence of ulcers, necrosis, inflammation, pleomorphism and mitosis were evaluated. Ki-67 biomarker was used immunohistochemically to demonstrate cell division. Based on histopathological and immunohistochemical examinations, it was determined that epitheliomas would rather be classified as low-grade malignancy due to the apparent mitotic activity and should be examined in more detail.