Catalytic Difunctionalization of Alkenes under Visible Light Irradiation: Synthesis of Iminofuranones
Comprehensive Summary Here, we show a cost‐effective and environmentally friendly method for synthesizing iminofuranones using visible light and the photocatalyst 2‐bromoanthraquinone. Our approach uses only oxygen as the oxidant, avoiding the need for additional transition metals and strong oxidizing agents. By employing a mixed solvent system of DMF and CHCl 3 under ambient conditions, we have achieved highly diastereoselective conversions of various 2‐vinyl benzamides and alkenyl amides into functionalized iminoisobenzofuranones and iminofuranones. This versatile process is broadly applicable and enables late‐stage structural modifications of complex substrates with bioactive moieties.
Authors
- Mingqiang Huang (ORCID: https://orcid.org/0000-0003-0969-0565)
- Guangxian Chen
- Feiming Li (ORCID: https://orcid.org/0009-0002-3963-4847)
- Fei Yan (ORCID: https://orcid.org/0000-0002-1702-0644)
- Zhixiong Cai (ORCID: https://orcid.org/0000-0002-6458-870X)
- Lina Cai (ORCID: https://orcid.org/0000-0003-2598-8388)
- Shunyou Cai (ORCID: https://orcid.org/0000-0001-8959-245X)
- Lele Zhang (ORCID: https://orcid.org/0000-0001-6617-9726)
- Boyu Liu (ORCID: https://orcid.org/0000-0001-5645-005X)
Institutions
- BGI Group (China) (CN)
- Shenzhen University (CN)
- Peking University (CN)
- Minnan Normal University (CN)
Publication Details
- Journal
- Chinese Journal of Chemistry
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1002/cjoc.202401116
- Citations
- 2
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province