Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept
Podophyllotoxin exerts toxic effects by altering autophagy through the AMPK/TSC1/mTOR/ULK1 signalling pathway. This study provides new insights into the mechanism of the toxic effects of podophyllotoxin and new ideas for the clinical application of podophyllotoxin.
Authors
- Yanzhao Zhang
- Mingyue Wei (ORCID: https://orcid.org/0000-0003-4982-2526)
- Zilong Chen (ORCID: https://orcid.org/0000-0003-4467-8537)
- Jiajia Duan (ORCID: https://orcid.org/0000-0002-7587-1789)
- Junjie He (ORCID: https://orcid.org/0000-0001-6447-7893)
- Huifeng Ma
- Jingjing Li (ORCID: https://orcid.org/0000-0003-3636-0537)
- Chuanxin Liu
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Henan University of Science and Technology (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1016/j.ecoenv.2024.117617
- Citations
- 6
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 1.40