Telomeric RNA quadruplexes as targets for cancer prevention: The therapeutic potential of agonodepsides
Lichenized fungi produce agonodepsides A and B, may fight cancer by targeting telomeres. Agonodepside A binds more strongly to telomeres than B, potentially blocking enzyme telomerase. Further studies are required to validate these findings and evaluate potential safety concerns.
Authors
- Anas Shamsi (ORCID: https://orcid.org/0000-0001-7055-7056)
- Gourav Choudhir (ORCID: https://orcid.org/0000-0001-6944-4652)
- Asimul Islam (ORCID: https://orcid.org/0000-0001-9060-7970)
- Mohammad Shahid (ORCID: https://orcid.org/0000-0002-9659-2041)
- Sushil Kumar (ORCID: https://orcid.org/0000-0002-1527-7059)
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
- Ajman University (AE)
- Seva Mandir (IN)
- Jamia Millia Islamia (IN)
Publication Details
- Journal
- Journal of Genetic Engineering and Biotechnology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1016/j.jgeb.2024.100454
- Citations
- 6
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Jamia Millia Islamia
- Ajman University